First off.. these interactive disks aren't anything like you think they are. Of course handbrake won't understand the iso.. because it's not a video format that you have copied.. and chances are it's seriously copy protected as well so imgburn won't make a working copy. These things have to be treated like a multi-menu/episode dvd.. so you are probably going to have to identify every video segment and then get creative. We have been down this road time and time again wit various interactive disks and only occasionally has anybody been able to get anything like the original functionality.. they use some real clever coding buried in the control files to address dvd player registers directly (yeah.. I know how to make interactive disks but I'm not teaching anybody else.. took me years to learn how.. I spent years researching and reading and experimenting.. don't see why I should give that away)

So.. to recap.. FIRST.. Make a working burned disk of what you are trying to copy.. it will be protected so try a proper dvd ripping program like dvd-fab.. THEN see how the iso is put together and what files are where. Only then can you see if it's a normal type dvd with menus or some funky computer disk with embedded programs.