After reading this post http://forums.afterdawn.com/thread_view.cfm/4/379152
I wanted to reiterate and update the information I got from adscorp. I have tried on and off for a few years to create, edit, and manage my playlists on my e250 with limited success. adscorp gives a link here to the SansaManager which is now broken. However, I did find the SansaManager here!

http://sourceforge.net/projects/sansamanager/

Source Forge is a well know and very reliable source for many tools, so I had no reluctance about trying the program out and sure enough... IT'S FANTASTIC!!!

Finally a program that works well and easily with my player. I just wanted to take the time to thank adscorp and pass on the new link to anybody with a Sansa player.

Thanks again adscorp!