I need a backup program that can run from a USB flash drive or USB external drive. The problem with normal backup programs is that often when I stick the USB drive in, the drive letter changes so then I have to go into the program and change it for every profile. If it ran from the USB drive then it wouldn't matter what the letter was.
maybe u can just run the backup program through bootable disk, which would not do anything to your system. here's an article about backup from winpe bootable disk.