Yes. but they're not ISOs, they're ROMs. I won't go into details. You'll need several things: - An M3 (or similar) - A media card (SD, miniSD, microSD or CF, depending what M3 you get) - A passcard3 so you can load games form the GBA slot in DS mode. - a Card Reader for your SD, miniSD, microSD or CF card You can read my guidefor M3 usage instructions, as well as where to get everything.