Files getting deleted on there own

Im running vista home in for some reason it is deleteing files ,tool bars keep disappering then comeing back.Plus its deleteing short cuts that have,anyone know what cause's this it just started yesturday,also when I do a system restore I can get everthing back but all my cd lables that I had stored.any help ID app it.
Also on a side note don't know if this matter's or not but most of the programs have to do with xbox 360 that its deleteing,like xbox backup creator,xbins,and so on.