Depends what the rest of the system is like. A basic board like an EP43-UD3L is fine for most PCs, an EP45 is a better bet for a quad core or if you overclock a lot.
i dont mess with over clocking. The rest of the componets read like this: 4x ddr2 1 meg sticks (corsair) 800mhz GTX8800 graffix card Blue ray dvd writer 2+ 500gig sata hard discs