System: MSI Neo2 (MS-7025) Platinum Motherboard AMD Athlon 64 X2 4200+ 2 Gig Generic Ram PNY GeForce 6600 DDR 256MB AGP card SoundBlaster Audigy sound card 3 1/2 inch Floppy Drive (Generic) 40 Gig EIDE HDD- Western Digital 80 Gig SATA HDD not RAID - Maxtor 80 Gig SATA HDD not RAID - Maxtor CD/DVDRW Toshiba (OEM) 620 Watt Enermax PSU, Modular connections except MoBo. XP Pro with Service Pack 2 Bios is version 1.9 from MSI NOTE: This unit never touches the web and has no contact with other computers. Data loaded that may have Cooties has been scanned and tested for same before leaving the source. System Mechanic 6 is used for software maintenance along with a few test/screening programs. Problem: Removed original CPU (AMD 3000+, Socket 939) and replaced with the 4200+ mentioned above but it took awhile to seat correctly with some board flex involved. All connections checked prior to power-up, CPU seated correctly and Heatsink in place. When power was applied, all the fans came up including the CPU unit and video card, there are power lights lit on A: (3.5 Floppy), C: (40 Gig), and the 80s but no activity lights and no P.O.S.T. First shot: Reinstalled old CPU and rechecked all connections...No P.O.S.T....damn. Second shot: Installed new CPU again, disconnected ALL wiring and applied jumper to reset the BIOS. Installed all wiring and confirmed RAM was well mounted in place, confirmed CPU was seated correctly after examining all pins...again, set jumper to operation position for BIOS and hit the switch.....no joy, just the same as before. Question: Dead motherboard? or bad karma?