I have had the same problem as all of you. Just upgraded to Vista Ultimate and now Epson Print CD will not print ! I tried what greenclaw suggested with the compatibility tab, but it still wouldn't print. However I have now found a way, and just tried and tested my theory and it works, so give this a go if you are still having problems : 1. Open Print CD. 2. Select File > Print. 3. Select 'Manual Print'. 4. Select your printer (from the drop down list). 5. Select 'Properties'. 6. Set 'Source' to Manual. 7. Set 'Type' to CD/DVD. 8. Click OK and Click OK again for the CD to Print. Worked for me several times now - hope it works for you !!!