i've never had this problem before... but since i installed SP2 last week, out of no where my mouse will move up and to the left by itself. I thought this was a virus or someone hacking the PC, so i reformatted, and reinstalled while staying off-line... but still does it. I have an optical Logitech mouse that i've had for years with no problem... i thought i was the mouse pad, took it off the pad and it still does it. does SP2 do this on purpose or what? and WHY? Thanks all!
Also - your mouse could be going bad. I had two die on me that acted like you describe. Try swapping it with a known working mouse if you have a spare lying around (or borrow a friends), and see if you have the same results. If it uses batteries, change the batteries with fresh ones.